The Journal of Pediatrics
Volume 143, Issue 6 , Pages 725-730 , December 2003

Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomized, placebo-controlled trial

Received 2 November 2002 ,Revised 5 June 2003 ,Accepted 7 August 2003.

References 

  1. Milner AD. The role of corticosteroids in bronchiolitis and croup. Thorax. 1997;52:595–597
  2. Brunette MG, Lands L, Thibodeau LP. Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infection. Pediatrics. 1988;81:624–629
  3. Storr J, Barrel E, Barry W, Lenney W, Hatcher G. Effect of a single oral dose of prednisolone in acute childhood asthma. Lancet. 1987;1:879–882
  4. Gleeson JG, Loftus BG, Price JF. Placebo controlled trial of systemic corticosteroids in acute childhood asthma. Acta Paediatr Scand. 1990;79:1052–1058
  5. Tal A, Levy N, Bearman J. Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial. Pediatrics. 1990;86:350–356
  6. Scarfone RJ, Fuchs SM, Nager AL, Shane SA. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics. 1993;92:513–518
  7. Horowitz L, Zafrir O, Gilboa S, Berger I, Wolach B. Acute asthma: single dose oral steroids in paediatric community clinics. Eur J Pediatr. 1994;153:526–530
  8. Webb MS, Henry RL, Milner AD. Oral corticosteroids for wheezing attacks under 18 months. Arch Disease Child. 1986;61:15–19
  9. Springer C, Bar-Yishay E, Uwayyed K, Avital A, Vilozni D, Godfrey S. Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis. Pediatr Pulmonol. 1990;9:181–185
  10. Roosevelt G, Sheehan K, Grupp-Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet. 1996;348:292–295
  11. Klassen TP, Sutcliffe T, Watters LK, Wells GA, Allen UD, Li MM. Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: a randomised, controlled trial. J Pediatr. 1997;130:191–196
  12. Bülow SM, Nir M, Levin E, Friis B, Thomsen LL, Nielsen JE, et al. Prednisolone treatment of respiratory syncytial virus infection: a randomized controlled trial of 147 infants. Pediatrics [serial online] 1999;104:e77. Available from: URL:http://www.pediatrics.org/cgi/content/full/104/6/e77.
  13. Daugbjerg P, Brenoe E, Forchhammer H, Frederiksen B, Glazowski MJ, Ibsen KK, et al.  A comparison between nebulized terbutaline, nebulized corticosteroid and systemic corticosteroid for acute wheezing in children up to 18 months of age. Acta Paediatr. 1993;82:547–551
  14. van Woensel JB, Wolfs TF, van Aalderen WM, Brand PL, Kimpen JL. Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis. Thorax. 1997;52:634–637
  15. Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic corticosteroids in infant bronchiolitis: a meta-analysis. Pediatrics [serial online] 2000;105:e44. Available from: URL:http://www.pediatrics.org/cgi/content/full/105/4/e44.
  16. Schuh S, Coates AL, Binnie R, Allin T, Goia C, Corey M, et al.  Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J Pediatr. 2002;140:27–32
  17. Tabachnik E, Levison H. Infantile bronchial asthma. J Allergy Clin Immunol. 1981;67:339–347
  18. Korppi M, Mäkelä M, Vanto T. Obstruktiivinen bronkiitti. In:  Ruuskanen O,  Peltola H,  Vesikari T editor. Lasten infektiosairaudet. 2nd ed. Helsinki, Finland: Pfizer, Inc; 2000;p. 142–147
  19. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ, et al.  Asthma and wheezing in the first six years of life. N Engl J Med. 1995;332:133–138
  20. Martinez FD, Morgan WJ, Wright AL, Holberg CJ, Taussig LM. Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. N Engl J Med. 1988;319:1112–1117
  21. Taussig LM. The conundrum of wheezing and airway hyperreactivity in infancy. Pediatr Pulmonol. 1992;13:1–3
  22. Korppi M, Halonen P, Kleemola M, Launiala K. Viral findings in children under the age of two years with expiratory difficulties. Acta Paediatr Scand. 1986;75:457–464
  23. Rakes GP, Arruda E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, et al.  Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care: IgE and eosinophil analyses. Am J Respir Crit Care Med. 1999;159:785–790
  24. Szefler SJ. Challenges in assessing outcomes for pediatric asthma. J Allergy Clin Immunol. 2001;107:S456–S464

☆ Supported by grants from the Emil Aaltonen Foundation; the Finnish Allergy Research Foundation; the Foundation for Pediatric Research, Finland; the Medical Research Fund of Tampere University Hospital; the Support Fund for the Department of Pediatrics; the Tampere University Research Foundation; and the Tuberculosis Foundation of Tampere.

PII: S0022-3476(03)00498-0

doi: 10.1067/S0022-3476(03)00498-0

The Journal of Pediatrics
Volume 143, Issue 6 , Pages 725-730 , December 2003

Article Tools

* Image Usage & Resolution