The Journal of Pediatrics
Volume 138, Issue 1 , Pages 125-128 , January 2001

Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children

Received 9 August 1999 ,Revised 9 June 2000 ,Accepted 19 June 2000.

References 

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  5. Hamm LR, Sorrells SC, Harding JP, Northcutt AR, Heath AT, Kapke GF, et al.  Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome criteria. Am J Gastroenterol. 1999;94:1279–1282
  6. Jones OR. Essence of peppermint, a history of the medicine and its bottle. Historical Archaeology. 1981;15:1–39
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  14. Nolon HW, Friend DR. Mental B-D-glucuronide: a potential prodrug for treatment of the irritable bowel syndrome. Pharm Res. 1994;2:1707–1711
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  17. Dew MI, Evans BK, Rhodes J. Peppermint oil for the irritable bowel syndrome: a multicenter trial. Br J Clin Pract. 1984;38:394–398
  18. Liu JH, Chen GH, Yeh HZ, Huang CK, Poon SK. Enteric-coated peppermint oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol. 1997;32:765–768
  19. Weiss W, Koelbl C. Therapie little des. Irritable mit pfesserminzolkapsen. Therapie Woche Osterreich. 1988;2:193–199
  20. Nash P, Guold SR, Barnard DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract. 1986;40:292–293
  21. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol. 1998;93:1131–1135
  22. Somerville KW. Delayed release peppermint oil capsules for the spastic colon syndrome: a pharmacokinetic study. Br J Clin Pharmacol. 1984;18:638–640
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  25. Barbero GJ. Recurrent abdominal pain in childhood. Pediatr Rev. 1982;3:29–34

☆ †Dr Barbero died November 1, 1998.

☆☆ Supported in part by a grant from Tillotts Pharma AG, Ziefen, Switzerland.

★ Reprint requests: Robert Kline, PhD, 2000 East Broadway, Suite 108, Columbia, MO 65201.

PII: S0022-3476(01)95069-3

doi: 10.1067/mpd.2001.109606

The Journal of Pediatrics
Volume 138, Issue 1 , Pages 125-128 , January 2001

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