Growth hormone deficiency caused by pituitary stalk interruption in Fanconi’s anemia☆

Received 22 December 1999; received in revised form 24 April 2000; accepted 7 June 2000.

Abstract

Fanconi’s anemia can be associated with growth retardation. We describe biologic growth hormone deficiency, isolated or associated with thyrotropin abnormality, and pituitary stalk interruption syndrome on magnetic resonance imaging of 5 patients with Fanconi’s anemia. Growth hormone treatment produced catch-up growth in all cases. These findings suggest a common genetic origin. (J Pediatr 2001;138:129-33)

Abbreviations: FA , Fanconi’s anemia, GH , Growth hormone, IGF-1 , Insulin growth factor-1, MRI , Magnetic resonance imaging, PSIS , Pituitary stalk interruption syndrome, TRH , Thyrotropin-releasing hormone

Pediatric Endocrinology and Immuno-Hematology Departments, Physiology Laboratory, Université René Descartes and Hôpital Necker-Enfants Malades, Paris; and Bone Marrow Transplantation Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France

☆ Reprint requests: Sophie Dupuis-Girod, MD, Unité d’immunologie et d’hématologie pédiatriques, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75015 Paris, France.

PII: S0022-3476(01)06424-1

doi:10.1067/mpd.2001.109200

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