Isolated pancreatic amylase deficiency: Probable error in maturation

Mehta, Devendra I.; Wang, Hugh H.; Akins, Robert E.; Wang, Lisa; Proujansky, Roy

« Previous Next »The Journal of Pediatrics
Volume 136, Issue 6 , Pages 844-846, June 2000

Isolated pancreatic amylase deficiency: Probable error in maturation

Devendra I. Mehta, MD
- Division of Gastroenterology, Department of Pediatrics
- Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware.
- Reprint requests: Devendra I. Mehta, MD, Division of Gastroenterology, Alfred I. duPont Hospital for Children, 1600 Rockland Rd, PO Box 269, Wilmington, DE 19899.
Hugh H. Wang, PhD
- Division of Gastroenterology, Department of Pediatrics
- Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware.
Robert E. Akins, PhD
- Division of Gastroenterology, Department of Pediatrics
- Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware.
Lisa Wang, MS
- Division of Gastroenterology, Department of Pediatrics
- Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware.
Roy Proujansky, MD
- Division of Gastroenterology, Department of Pediatrics
- Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware.

Received 27 August 1999; received in revised form 29 December 1999; accepted 6 January 2000.

A boy with failure to thrive and isolated pancreatic amylase deficiency is described. Immunoprecipitation confirmed only salivary isoamylase in duodenal fluid at ages 20 and 33 months. Because normal pancreatic amylase messenger RNA was detected by reverse-transcriptase polymerase chain reaction in the fluid, failure of the normal maturation of pancreatic amylase secretion may explain the deficiency.

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