Sugar-Sweetened Beverages, Serum Uric Acid, and Blood Pressure in Adolescents
Received 29 August 2008; received in revised form 25 November 2008; accepted 9 January 2009. published online 20 April 2009.
Refers to article:
Sour Notes on Sweet Drinks
Daniel I. Feig
The Journal of Pediatrics
June 2009 (Vol. 154, Issue 6, Pages 783-784) Full Text |
Full-Text PDF (117 KB)
Objective
To evaluate whether sugar-sweetened beverage consumption, a significant source of dietary fructose, is associated with higher serum uric acid levels and blood pressure in adolescents.
Study design
We analyzed cross-sectional data from 4867 adolescents aged 12 to 18 years in the National Health and Nutrition Examination Survey, 1999-2004. Dietary data were assessed from 24-hour dietary recall interviews. Sugar-sweetened beverages included fruit drinks, sports drinks, soda, and sweetened coffee or tea. We used multivariate linear regression to evaluate the association of sugar-sweetened beverage consumption with serum uric acid and with blood pressure.
Results
Adolescents who drank more sugar-sweetened beverages tended to be older and male. In the adjusted model, serum uric acid increased by 0.18 mg/dL and systolic blood pressure z-score increased by 0.17 from the lowest to the highest category of sugar-sweetened beverage consumption (P for trend, .01 and .03, respectively).
Conclusions
These results from a nationally representative sample of US adolescents indicate that higher sugar-sweetened beverage consumption is associated with higher serum uric acid levels and systolic blood pressure, which may lead to downstream adverse health outcomes.
aDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, Arthritis Research Centre of Canada, Vancouver General Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
cDepartment of Medicine, University of California, San Francisco, CA
Reprint requests: Dr Stephanie Nguyen, UCSF Children's Renal Center, 533 Parnassus Avenue, Box 0748, San Francisco, CA 94131-0748
S.N. was supported by the American Heart Association (0725258Y) and the Department of Pediatrics, University of California San Francisco. C-y.H. was supported by NIH DK70939 and DK67126.
ABSTRACT