The Journal of Pediatrics
Volume 141, Issue 4 , Pages 576-581, October 2002

Eosinophil-associated gastrointestinal disorders: A world-wide-web based registry☆☆☆

Division of Allergy and Immunology, the Division of Pathology, and the Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, and the Department of Psychology, Ohio University, Athens, Ohio

Received 18 February 2002; received in revised form 22 April 2002 and 31 May 2002; accepted 19 June 2002.

Abstract 

A world wide web database was established that tracked features of eosinophil-associated gastrointestinal disorders; 80% had coexisting atopic disease, 62% had food sensitization, and 16% had an immediate family member with a similar disorder. Developmental delay, seizure disorders, and congenital anomalies were seen in a proportion of respondents. The world wide web has proven to be an efficient tool to gather patient information, allowing us to define distinguishing features of various eosinophil-associated gastrointestinal disorders and to establish that these disorders have strong genetic and allergic components. (J Pediatr 2002;141:576-81)

Abbreviations:  EC , Eosinophilic colitis, EE , Eosinophilic esophagitis, EGE , Eosinophilic gastroenteritis, EGID , Eosinophil-associated GI disorders, GI , Gastrointestinal, WWW , World wide web

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☆ Supported in part by National Institutes of Health grants R01 AI42242-04 and R01 AI45898-03, the Human Frontier Science Program, the International Life Sciences Institute (ILSI), and the Burroughs Wellcome Fund Translational Research grant (all granted to M. E. R.).

☆☆ Reprint requests: Marc E. Rothenberg, MD, PhD, Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229.

PII: S0022-3476(02)00145-2

doi:10.1067/mpd.2002.127663

The Journal of Pediatrics
Volume 141, Issue 4 , Pages 576-581, October 2002

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