The Journal of Pediatrics
Volume 132, Issue 3 , Pages 452-454, March 1998

Decreased growth hormone response to glucagon in infants after an apnea of infancy☆☆☆★

Received 25 November 1996; accepted 30 May 1997.

Abstract 

We studied glucagon-induced growth hormone secretion in 9 patients with apnea of infancy and in 55 siblings of children who had died of sudden infant death syndrome, who were included as a comparison group. We observed a 33% decrease in growth hormone secretion in patients with apnea of infancy. However, linear growth remained normal. This finding could be related to either repeated episodes of hypoxia or to abnormal maturation of the autonomous nervous system. (J Pediatr 1998;132:452-4)

Abbreviations:  ALTE , Apparent life-threatening event, AOI , Apnea of infancy, GH , Growth hormone, SDS , Standard deviation score, SIDS , Sudden infant death syndome

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☆ From the Hôpital Universitaire des Enfants Reine Fabiola, Free University of Brussels, Brussels, Belgium, and Hôpital Sainte-Justine, University of Montreal, Montreal, Canada.

☆☆ Reprint requests: Jean-Pierre Chanoine, MD, Endocrinology & Diabetes Unit, Room 1A46, 4480 Oak St., Vancouver, B.C., V6H3V4, Canada.

★ 9/21/83677

PII: S0022-3476(98)70019-8

The Journal of Pediatrics
Volume 132, Issue 3 , Pages 452-454, March 1998

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