The Journal of Pediatrics
Volume 125, Issue 5 , Pages 819-822, November 1994

Increased risk of facial scars in children taking nonsteroidal antiinflammatory drugs☆☆☆★

Received 4 April 1994; accepted 28 June 1994.

Abstract 

Children with rheumatic disease (N = 250) were examined for shallow facial scars similar to those described in drug-induced pseudoporphyria. Users of a nonsteroidal antiinflammatory drug were 2.4 times as likely as nonusers to have four or more facial scars; this relative risk was increased to 6.0 in users of naproxen. (J PEDIATR 1994;125:819-22)

Abbreviations:  NSAID , Nonsteroidal antiinflammatory drug

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☆ From the Department of Pediatrics, University of Washington and Children's Hospital and Medical Center, Seattle, and the Department of Epidemiology, University of Washington and Virginia Mason Medical Center, Seattle

☆☆ Reprint requests: Carol A. Wallace, MD, Rheumatology CH-73, Children's Hospital and Medical Center, 4800 Sand Point Way N.E., Seattle, WA 98105-0371.

★ 0022-3476/94/$3.00 + 0 9/26/58760

PII: S0022-3476(94)70084-2

The Journal of Pediatrics
Volume 125, Issue 5 , Pages 819-822, November 1994

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