LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents☆☆☆★★★
Abstract
Two adolescents with a long history of abuse of lysergic acid diethylamide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syndrome. The similarity in neuroreceptor physiology for both LSD and serotonin suggests that the LSD flashback syndrome may be induced by these drugs in patients with a history of LSD abuse. (J PEDIATR 1994;125:817-9)
Abbreviations: LSD , Lysergic acid diethylamide, SSRI , Selective serotonin reuptake inhibitor, 5-HT , 5-Hydroxytryptamine
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☆ From the Departments of Pediatrics and Communicable Diseases, and Pharmacology, University of Michigan Medical School, Ann Arbor
☆☆ Supported in part by a National Research Service Award (Dr. Markel), National Institutes of Health, National Center for Human Genome Research (grant No. 5 F32 HG00037-02).
★ Reprint requests: Howard Markel, MD, PhD, Assistant Professor of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1924 Taubman Center, Box 0318, Ann Arbor, MI 48109.
★★ 0022-3476/94/$3.00 + 0 9/26/58251
PII: S0022-3476(94)70083-4
© 1994 Mosby, Inc. All rights reserved.
