Effect of Levo-Thyroxine Treatment on Weight and Body Mass Index in Children with Acquired Hypothyroidism
Objective
To determine whether normalization of thyroid-stimulating hormone (TSH) in children with acquired hypothyroidism is associated with a decrease in weight or body mass index (BMI).
Study design
We retrospectively identified 68 subjects with acquired hypothyroidism who were seen at least once in our center in follow-up between 1995 and 2006.
Results
Treatment with levo-thyroxine decreased the mean TSH level from 147 μU/mL initially to 5.0 μU/mL at the second visit 4.4 months later. This was not associated with a significant change in weight or BMI. Of the 68 subjects, 31% lost weight by the second visit (mean 2.3 kg). The mean initial TSH level of this group was 349 μU/mL. Thirty of the 68 children had at least 2 years of follow-up, and 19/68 had at least 4 years of follow-up. Over those intervals, weight and BMI percentiles and z scores did not change significantly from baseline values.
Conclusions
Most children treated for acquired hypothyroidism exhibited little short-term or long-term change in weight or BMI despite near-normalization of TSH. Those children who lost weight tended to have severe hypothyroidism and to have only a small weight loss. Consequently, practitioners should not expect significant decreases in weight after treatment in most children with hypothyroidism.
Abbreviations: ATP, Adenosine triphosphate, BMI, Body mass index, BMR, Basal metabolic rate, TSH, Thyroid-stimulating hormone
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PII: S0022-3476(07)00564-1
doi:10.1016/j.jpeds.2007.06.006
© 2008 Mosby, Inc. All rights reserved.
