Breast-Feeding Duration and Infant Atopic Manifestations, by Maternal Allergic Status, in the First 2 Years of Life (KOALA Study)
Received 2 August 2006; received in revised form 19 December 2006; accepted 15 March 2007. published online 15 July 2007.
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Objective
To investigate the potential effect of modification by maternal allergic status on the relationship between breast-feeding duration and infant atopic manifestations in the first 2 years of life.
Study design
Data from 2705 infants of the KOALA Birth Cohort Study (The Netherlands) were analyzed. The data were collected by repeated questionnaires at 34 weeks of gestation and 3, 7, 12, and 24 months postpartum. Total and specific immunoglobulin E measurements were performed on venous blood samples collected during home visits at age 2 years. Relationships were analyzed using logistic regression analyses.
Results
Longer duration of breast-feeding was associated with a lower risk for eczema in infants of mothers without allergy or asthma (Ptrend = .01) and slightly lower risk in those of mothers with allergy but no asthma (Ptrend = .14). There was no such association for asthmatic mothers (Ptrend = .87). Longer breast-feeding duration decreased the risk of recurrent wheeze independent of maternal allergy (Ptrend = .02) or asthma status (Ptrend = .06).
Conclusions
Our findings show that the relationship between breast-feeding and infant eczema in the first 2 years of life is modified by maternal allergic status. The protective effect of breast-feeding on recurrent wheeze may be associated with protection against respiratory infections.
aCare and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
bNutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands
cDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands; Department of Medical Microbiology, University Hospital of Maastricht, Maastricht, The Netherlands
dDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
Reprint requests: Bianca Snijders, MSc, Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.
Supported by The Netherlands Organisation for Health Research and Development (Zon-Mw), program of Innovative Prevention Research (Prevention Program 1, no. 210-00-090).
The sponsoring organization had no involvement in the study design, data collection, analysis, or interpretation, or in writing of the report or the decision to submit the manuscript for publication. There are no conflicts of interest to report.
ABSTRACT